I have a Harmony 515 remote that i use to control the TV, Humax, Blu-Ray and Xbox. When you create the "watch TV" activity, you assign it the TV and Humax and then any button can control anything on either device. So P+/- controls channel on the Humax and V+/- controls volume on the TV.
I'd quite like to program the mute button to kill the sound on the TV and turn on subtitles on the humax but the humax wont seem to turn them off again afterwards.
Took a bit of setting up but one of the best gadgets I have ever brought.